[SCIENCE MONDAY] - Antibodies against MAP and HERV epitopes are elevated in T1D children, supporting their potential role in disease onset and severity

MAP and HERVs have been proposed as T1D triggers via molecular mimicry. Using ELISA, this study assessed antibodies against MAP, HERV-W, and HERV-K epitopes in newly diagnosed Tunisian T1D children, healthy siblings, and controls. T1D patients showed elevated antibody prevalence, with stronger reactivity in diabetic ketoacidosis cases. Antibody levels correlated with neutrophil count and neutrophil-to-lymphocyte ratio, supporting MAP and HERV involvement in T1D pathogenesis. 

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