[SCIENCE MONDAY] - Marine sulfated polysaccharides as biofunctional agents for enhancing hemocompatibility and endothelialization of tissue-engineered vascular grafts

Small-diameter vascular grafts continue to face high failure rates due to thrombosis, intimal hyperplasia, and inadequate endothelialization. Marine sulfated polysaccharides (MSPs) have emerged as biofunctional agents capable of modulating coagulation, inflammation, and vascular cell behavior. This review brings together current insights into MSPs structure–function relationships and how these features can be strategically harnessed for vascular graft design and clinical translation.

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