[SCIENCE MONDAY] - The study shows oxidized LDL harms male HUVECs more than female ones before birth, potentially affecting future heart disease risk

The study shows that oxidized LDL (ox-LDL) induces sex-specific responses in endothelial cells from newborns. Male cells display higher oxidative stress, mitochondrial dysfunction, inflammation and apoptosis, while female cells better preserve mitochondrial function and activate adaptive mechanisms such as autophagy. These early differences may contribute to sex-specific cardiovascular risk later in life.

You can read the article in the following link: